Research

My primary long-standing interest has been translational drug discovery research. My current focus of research is Translational Neuroscience which includes understanding the molecular and cellular mechanisms underlying synaptic plasticity, learning, and memory. In my current work, I investigate how alterations in neurotrophin signalling and other key molecules within specific neuronal populations affect neural circuit development and function. Through this research, I aim to elucidate the contributions of these molecular changes to cognitive disorders, basal ganglia movement disorders, and metabolic dysfunctions.

Over the years, has spanned multiple facets of translational drug discovery including pathomechanisms, preclinical pharmacokinetics, biomarker studies, and drug delivery. My investigations into pharmacokinetics have provided critical insights into the metabolic fate and safety profiles of drug candidates, essential for advancing treatments toward clinical trials. Additionally, I have advanced chromatographic methods to precisely quantify biomarkers and drug levels in biological samples, enhancing our ability to monitor disease progression and treatment efficacy. My multidisciplinary approach bridges analytical chemistry, pharmacology, and neuroscience, reflecting a commitment to pushing the boundaries of translational research for neurological and metabolic health.

My D.Phil degree and subsequent job as a Postdoctoral Neuroscientist were in the area of drug Metabolism and Pharmacokinetics (DMPK) studies supporting the drug development programme of the Central Drug Research Institute (CDRI), India's premier drug research institute.

This includes scientific expertise in study design, execution, and data analysis of in vitro and in vivo ADME/DMPK studies and dedicated project management:

  • Bioanalysis using LC-MS/MS and HPLC
  • Cytochrome P450 Interaction Assays
  • Metabolite profiling
  • SOLVO drug transporter assays
  • Pharmacokinetics / Toxicokinetics
  • Tissue distribution / QWBA

My master's (M.S) degree and subsequent role as a research fellow were in the area of drug Metabolism and Pharmacokinetics (DMPK) studies supporting the drug development programme of the Central Drug Research Institute (CDRI), India's premier drug research institute.

This includes scientific expertise in study design, execution, and data analysis of in vitro and in vivo ADME/DMPK studies and dedicated project management:

  • Bioanalysis using LC-MS/MS and HPLC
  • Cytochrome P450 Interaction Assays
  • Metabolite profiling
  • SOLVO drug transporter assays
  • Pharmacokinetics / Toxicokinetics
  • Tissue distribution / QWBA

I focus specifically in these areas:

  • {Area}—{A brief description of this area}
  • {Area}—{A brief description of this area}
  • {Area}—{A brief description of this area}
  • {Area}—{A brief description of this area}
  • {Area}—{A brief description of this area}
  • {Area}—{A brief description of this area}

Select Publications

Published Papers
  • LastName, P., & Lastname, Q. (1999). Book title goes here (2nd ed.) City, CA: Publishing House.
  • Lastname, X. (1999). Article title. Journal Title, 33(5), 100-110. doi:10.1099/1525.1999.12
  • Lastname, X. (1999). Article title. Journal Title, 33(5), 100-110. doi:10.1099/1525.1999.12
  • Lastname, X. (1999). Article title. Journal Title, 33(5), 100-110. doi:10.1099/1525.1999.12
Submitted for Publication
  • LastName, P., & Lastname, Q. (1999). Book title goes here (2nd ed.) City, CA: Publishing House.
  • Lastname, X. (1999). Article title. Journal Title, 33(5), 100-110. doi:10.1099/1525.1999.12
  • Lastname, X. (1999). Article title. Journal Title, 33(5), 100-110. doi:10.1099/1525.1999.12
  • Lastname, X. (1999). Article title. Journal Title, 33(5), 100-110. doi:10.1099/1525.1999.12
Working Papers
  • LastName, P., & Lastname, Q. (1999). Book title goes here (2nd ed.) City, CA: Publishing House.
  • Lastname, X. (1999). Article title. Journal Title, 33(5), 100-110. doi:10.1099/1525.1999.12
  • Lastname, X. (1999). Article title. Journal Title, 33(5), 100-110. doi:10.1099/1525.1999.12
  • Lastname, X. (1999). Article title. Journal Title, 33(5), 100-110. doi:10.1099/1525.1999.12

Dissertation

{ABSTRACT OF MY DISSERTATION}

{SAMPLE/QUOTE FROM YOUR DISSERTATION}
Yaseen Malik D.Phil

  Read More